# FDA Clears Extended-Release Nefopam Formulation and First OTC Acetaminophen-Naproxen Combo in July 2026

> fda · REPORTED · 2026-07-31

July 2026 brought several notable pain management developments, including FDA clearance of an investigational extended-release formulation of nefopam and the first OTC fixed-dose combination of acetaminophen and naproxen sodium. Positive phase 2b findings were also reported for a selective NaV1.8 inhibitor, a new non-opioid analgesic mechanism.

About Pain Management Sector: The pain management sector encompasses pharmaceutical and device-based interventions for acute and chronic pain, spanning OTC analgesics, novel non-opioid mechanisms, opioid stewardship, and implantable neuromodulation therapies.

- Company: Pain Management Sector
- Sector: therapeutics
- Primary source: https://www.pharmacytimes.com/view/july-2026-in-pain-management-10-developments-that-advanced-and-challenged-patient-care

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Source: MedFuel Intel news monitor. Verification tier: REPORTED. Informational only, not investment advice. Corrections: media@medfuelinc.com.